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Results from a blood-oxygen dependent functional MRI study [44] also suggest that mesolimbic reward-related areas may also mediate the anorectic effects of Ex in humans, with a hypothesised mechanism of decreasing responsiveness to contextual food cues (incentive salience, wanting) and increasing activity that correlates with consummatory reward value (liking) [45]

20 In addition, aspects of body composition that are not efficiently accounted for by simple measures of weight or body mass index (BMI) also appear to be important modifiers of mortality risk in CKD

At week 72, semaglutide demonstrated a meaningful improvement in liver outcomes compared with placebo

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